Where else to go but down for the Botwins. After Shane (Alexander Gould) clubbed Pilar (Kate del Castillo) at the end of season five, Nancy (Mary-Louise Parker) takes the band on the run. Silas (Hunter Parrish) reluctantly follows his family. Andy (Justin Kirk) blows it with his doctor girlfriend (Alanis Morissette) so he decides to help out the family. Later, Doug (Kevin Nealon) gets dragged into the escape, as Cesar (Enrique Castillo) and Ignacio (Hemky Madera) search for Esteban's son.
Season six makes perfect sense considering the trajectory of the show. Nancy ineptly climbed the drug industry career ladder, so once she got to the top it made sense she would fall and crash through the bottom floor. The Botwins try to go straight for about two minutes, before they start selling hash at a hotel, a trailer park, and a night club. Nancy doesn't adhere to Andy's rules for living off the grid, and eventually Esteban (Demián Bichir) catches up with them. The Botwins have truly hit rock bottom, and more than in any other season, Nancy comes close to losing her family. Silas almost leaves the family three times (once with his newly found biological father). Shane becomes more morbid and cynical. It's only by giving herself up that Nancy can finally make her family safe.