Season six drags a little because of the focus on Colleen's (Natalie Distler) drinking problem. Katy (Olivia Crocicchia) goes to boarding school and grows apart from Tommy and Janet (Andrea Roth). Through six seasons Tommy (Denis Leary) hasn't been able to get his family in order.
Budget cuts threaten the house, leading to classic Rescue Me action when they beat another house to a fire and save a school full of children without equipment. Needles (Adam Ferrara) battles Feinberg (Jerry Adler) over the cuts. Mickey (Robert John Burke) dates Sheila (Callie Thorne) behind Tommy's back. Mickey usually has moral superiority over Tommy. Turning the tables is always funny. The rest of the crew - Mike (Michael Lombardi), Sean (Steven Pasquale), Franco (Daniel Sunjata), Lou (John Scurti), and Shawn (Larenz Tate) - are their normal, mostly irreverent selves.
Damien (Michael Zegen) questions his commitment to firefighting before coming back and tragically getting paralyzed in a fire. The season ends with Tommy dealing with his role in Damien's choices.